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Database Contents
Org
Loci
Variations
Hs
23638
1307840
Mm
33230
120835
Rn
5943
13844
Dm
26367
42120
Ce
15741
1466
 

 

August 25, 2003
Sequence and variation data for Caenorhabditis elegans, Drosophila melanogaster and Rattus norvegicus have been added to the site. The human information has been updated to NCBI Build 33, GenBank Release 133 and dbSNP Build 111.

July 17, 2003
Users with Premium Access now have access to a feature that can automatically design amplicons for any number of exons in a gene with one command. (Premium Access is available to customers with active support contracts. Please see your ADS Biotec sales representative for more information.)

May 5, 2003
Sequence and variation data for the mouse genome have been added to the site. There have also been improvements in the workflow for DHPLC analysis. For premium users a tool for melt analysis has been developed. Several methods for calculating melt profiles and predicting melting temperatures are combined into a single user interface to guide the initial DHPLC oven temperature selection.

March 18, 2003
The site now has the ability to export mutationdiscovery.com amplicons for use with Navigator™, ADS Biotec's HPLC/DHPLC software for the WAVE™ and WAVE-MD™ systems. Support has been added for downloading a filtered list of variations in CSV format for a given locus. A number of enhancements have been made to the sequence alignment features.

January 22, 2003
Users are now able to share access to their features with groups of other users they have designated. A new module for amplicon design has been added for premium users. Regions of interest are indicated on a locus and a simple user interface provides access to a Primer3 based algorithm for generating the flanking primers. The resulting amplicon will be annotated back onto the MutationDiscovery locus sequence.

December 23, 2002
Enhanced performance and functionality of the locus sequence display. The system now supports multiple gene models per locus (these alternative models will show up over the course of the next few weeks as the most recent NCBI releases are loaded). The interface for selecting regions for annotating variations and amplicons has been improved. A pop-up tool for determining protocols for Optimase™-based PCR has been added.

September 15, 2002
User variation and amplicon data entry is now supported, allowing users to enter and share data with other registered users as desired. Human pseudogene data has been added to the site. Several enhancements, including codon numbering on protein coding regions, locus sequence searching using approximate string matching, and export of locus genomic sequences, are also now available on the site.

July 24, 2002
Enhanced gene and disease search from main page to search aliases (e.g., searching for "PXE" now brings back ABCC6, even though "PXE" exists only as a disease alias). Plus, several other minor fixes and enhancements.

July 8, 2002
First public release of the site.